Greenpeace protesters arrested at Rishi Sunak's North Yorkshire home
Campaigners had unfurled "oil-black fabric" on the house in a North Yorkshire village, Greenpeace said.
Two men and two women were arrested on suspicion of causing criminal damage and public nuisance after they returned to ground level at about 13:00 BST.
A third man was also arrested on suspicion of causing a public nuisance.
North Yorkshire Police said all those arrested remained in police custody.
Rishi Sunak's office confirmed neither the prime minister nor his family were present at the time.
One of the protesters had earlier they had scaled the building to "bring home to the prime minister the really serious consequences of a new drilling frenzy in the North Sea".
North Yorkshire Police said the force had been made aware of the incident at Mr Sunak's constituency home at about 08:05.
Officers had "contained the area" and no-one had entered the building, a spokesperson said.
A large cordon was put in place and specialist police liaison officers were used to bring the protesters down from the roof of the property, they added.
Assistant Chief Constable Elliot Foskett, said: "There was no threat to the wider public throughout this incident which has now been brought to a safe conclusion."
When asked about the incident, Deputy Prime Minister Oliver Dowden said he thought the British people were "sick of these stupid stunts".
Labour's shadow home secretary Yvette Cooper said the incident was "disgraceful".
"This is against the law and rightly the police are taking enforcement action.
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