Shericka Jackson of Jamaica talks up a tilt at Flo-Jo 200m record
Jackson ran the second fastest time in history - 21.45 seconds - to win gold in Eugene in July.
Griffith-Joyner won Olympic gold at Seoul 1988 in 21.34 seconds.
"I'm great at the 200m," said Jackson with a smile. "I am looking for a fast, fast time."
"At the World Championships I had a lot in my legs and was still able to run 21.4 seconds so to come out here, I expect to perform at my best."
Jackson played down fears that the timetable for the season finale in Zurich may hamper her.
She is also competing in the 100m final, 80 minutes before she runs in the longer distance.
"That recovery is enough for me. I want to challenge myself and I think here is the best place to do it," she added.
Jackson revealed that she set her World Championships-winning time as a goal earlier in the season and has since revised it downwards.
"Before this season I wrote that exact time on a piece of paper," she said.
"I left it on my trophy stand so every time I step in my house or go to training I know I have that target.... I wanted it so badly.
"I went back home [after the Worlds] and I wrote another time because I definitely want to go faster and I think I am capable of doing that.
"If it is not done tomorrow then definitely I come back next year and work even harder."
Asked if her new goal would break Joyner-Griffiths' world record, she replied that it was "definitely round about there".
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