US air attack targets more Iran-backed bases in Syria
Secretary of Defence Lloyd Austin said the strikes were in response to "continued attacks" on US bases in Iraq and Syria by Iran-backed fighters.
At least eight pro-Iran fighters were killed, a UK-based war monitor said.
It is the third time since 26 October that the US has carried out such air strikes.
They come amid rising tensions in the region due to the Israel-Hamas war.
Mr Austin confirmed the air strikes in a brief statement on Sunday, saying they were conducted against a training facility and a safe house near the cities of Albu Kamal and Mayadin in eastern Syria.
He added the attacks were ordered by President Joe Biden "to make clear that the United States will defend itself, its personnel, and its interests".
The Pentagon did not provide any details on the damage caused by the strikes, but the Syrian Observatory for Human Rights (SOHR), a UK-based monitoring group, said eight members of Iran-backed militias were killed in the attack.
Seven others were injured, SOHR said. Most of the victims were non-Syrian nationals.
The group added that the strikes destroyed a weapons depot around Abu Kamal, near the Iraq-Syria border, and a rocket launch platform near Mayadin.
Iran-backed militias had also fired rockets at US bases overnight, SOHR said, though no one was killed.
The monitor has since reported a total of six attacks on International Coalition bases in Syria since Monday morning.
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